Acyclovir, commonly prescribed for treating herpes outbreaks, typically starts to show its effects within a few days of starting treatment. However, the full benefits may take around 2-3 weeks to be fully effective in reducing symptoms and helping manage the condition. It's essential to follow your healthcare provider's instructions on dosage and frequency for optimal results. If you have concerns about how acyclovir is working for you personally, please consult with your healthcare provider or doctor for guidance tailored to your specific situation.