Yes, combining l-lysine with Valtrex may help reduce the transmission of herpes more effectively than just taking Valtrex alone. L-lysine is an amino acid that some people believe can help manage and prevent outbreaks of oral or genital herpes. While there is limited scientific evidence to support this claim, some individuals choose to use it in combination with antiviral medications like Valtrex for added protection against transmission. It's essential to consult your healthcare provider before making any changes to your treatment plan or starting new supplements.